Thrombotic Thrombocytopenic Purpura: A Rare Case Presenting with Splenic Infarction
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چکیده
منابع مشابه
Thrombotic Thrombocytopenic Purpura: A Rare Case Presenting with Splenic Infarction
Thrombotic Thrombocytopenic Purpura (TTP) is a hypercoagulable state, in which platelets aggregate and clot in the microvasculature. The majority of cases can be linked to ADAMST13 deficiencies, a protein responsible for cleaving VonWillibrand’s Factor (vWF). Hypo functional ADAMST13 results in un-mitigated vWF activity, leading to excessive platelet aggregation. Increased clotting leads to dec...
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Thrombotic thrombocytopenic purpura (TTP) consists of the pentad of thrombocytopenia, hemolytic anemia, fever, neurologic abnormalities, and renal disease. We present a case report of acute TTP following a bout of ischemic colitis. This report reminds the clinician that ischemic colitis can be an atypical presentation of TTP. The prompt recognition and treatment of this disease process resulted...
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Objective: Thrombotic thrombocytopenic purpura (TTP) is the most malignant variant of microangiopathy that usually presents by typical symptoms including thrombocytopenia, hemolytic anemia, neurological abnormalities, fever and renal impairment. Report of the Case: We report a 12-year-old male presented by cytopenia, fever, purpura on his extremities, seizure and lethargy. Peripheral blood sm...
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Thrombotic thrombocytopenic purpura (TTP) is mostly attributed to the presence of an autoantibody against ADAMTS-13, a metalloprotease that degrades ultralarge von Willebrand protein multimers. Accumulation of vWF multimers and systemic platelet aggregation lead to microangiopathic thrombosis, hemolytic anemia, and end-organ ischemia. Most patients respond to therapeutic plasma exchange (TPE), ...
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ژورنال
عنوان ژورنال: Hematology & Transfusion International Journal
سال: 2016
ISSN: 2469-2778
DOI: 10.15406/htij.2016.02.00035